Thesis Seminar by Abhishek Mukhopadhyay

Bone Morphogenetic Protein Mediated Neuronal Differentiation
A Thesis Seminar by
Abhishek Mukhopadhyay
Dr. John A Kessler’s Lab
August 18th 2pm
Searle Seminar Room
Abstract:
The bone morphogenetic proteins (BMPs) belong to the transforming growth factor
superfamily of secreted signaling molecules. BMPs signal by binding to the type I (BMPR1A, BMPR1B
and ALK2) and type II (BMPR2) receptors that phosphorylate downstream molecules like the SMADs
which translocate to the nucleus and regulate gene transcription. In development BMPs are involved
in multiple processes including progenitor patterning, lineage commitment, exit from cell cycle,
differentiation and apoptosis in different organ systems. We investigated the role of BMP signaling
in the differentiation of neuronal subtypes in the different regions of the nervous system. In the
cerebral cortex, BMP4 signaling mediated by BMPR1A and BMPR1B promotes the differentiation of PV
expressing interneurons and suppresses the differentiation of SST expressing interneurons from
committed OLIG1 lineage precursors. In the hypothalamus, BMP7 signaling mediated by BMPR1A is
important for the differentiation of OLIG1 lineage derived dopaminergic neurons and regulates
feeding. Finally, in the DRG, the BMP signaling effecter HeyL promotes TrkC+ neuronal
differentiation by antagonizing the faction of the Hey paralog Hey1. Overall, our findings support
a role for BMP signaling in the neuronal differentiation process in multiple regions of the nervous
system.

FlyerHeader-1

Bone Morphogenetic Protein Mediated Neuronal Differentiation

A Thesis Seminar by

Abhishek Mukhopadhyay

Dr. John A Kessler’s Lab

August 18th 2pm

Searle Seminar Room

Abstract:

The bone morphogenetic proteins (BMPs) belong to the transforming growth factor

superfamily of secreted signaling molecules. BMPs signal by binding to the type I (BMPR1A, BMPR1B

and ALK2) and type II (BMPR2) receptors that phosphorylate downstream molecules like the SMADs

which translocate to the nucleus and regulate gene transcription. In development BMPs are involved

in multiple processes including progenitor patterning, lineage commitment, exit from cell cycle,

differentiation and apoptosis in different organ systems. We investigated the role of BMP signaling

in the differentiation of neuronal subtypes in the different regions of the nervous system. In the

cerebral cortex, BMP4 signaling mediated by BMPR1A and BMPR1B promotes the differentiation of PV

expressing interneurons and suppresses the differentiation of SST expressing interneurons from

committed OLIG1 lineage precursors. In the hypothalamus, BMP7 signaling mediated by BMPR1A is

important for the differentiation of OLIG1 lineage derived dopaminergic neurons and regulates

feeding. Finally, in the DRG, the BMP signaling effecter HeyL promotes TrkC+ neuronal

differentiation by antagonizing the faction of the Hey paralog Hey1. Overall, our findings support

a role for BMP signaling in the neuronal differentiation process in multiple regions of the nervous

system.