Dombeck, Daniel, PhD
|Areas of Research||
Behavior Cognition Language, Brain Imaging, Cell Imaging & Electrophysiology, Learning & Memory, Systems Neuroscience
|NU Scholar Profile|
|Recent Publications on PubMed|
The neuronal activity underlying mammalian spatial navigation represents one of the most striking examples of behavioral correlation in the brain. We are interested in the cellular and circuit mechanisms responsible for the neuronal activity that allows mammals to navigate and find their way to specific destinations. To accomplish this, we develop and apply novel optical and genetic techniques to perform cellular and subcellular resolution imaging and manipulation of neuronal population activity in mice navigating in virtual reality environments. By understanding the navigation circuitry, we hope to extract general principles about neuronal population dynamics in behaving mammals.
Dombeck DA, Harvey CD, Tian L, Looger LL, Tank DW (2010). Functional imaging of hippocampal place cells at cellular resolution during virtual navigation. Nature Neuroscience. 13(11), 1433-1440.
Dombeck DA, Graziano MS, Tank DW. (2009). Functional clustering of neurons in motor cortex determined by cellular resolution imaging in awake behaving mice. J Neurosci. Nov 4;29(44):13751-60.
Harvey CD, Collman F, Dombeck DA, Tank DW. (2009). Intracellular dynamics of hippocampal place cells during virtual navigation. Nature. Oct 15;461(7266):941-6.
Dombeck DA, Khabbaz AN, Collman F, Adelman TL, Tank DW. (2007). Imaging large-scale neural activity with cellular resolution in awake, mobile mice. Neuron. Oct 4;56(1):43-57.
Sacconi L, Dombeck DA, Webb WW. (2006). Overcoming photodamage in second-harmonic generation microscopy: real-time optical recording of neuronal action potentials. Proc Natl Acad Sci USA. Feb 103, 3124-3129.
Dombeck DA, Sacconi L, Blanchard-Desce M, Webb WW. (2005). Optical recording of fast neuronal membrane potential transients in acute mammalian brain slices by second-harmonic generation microscopy. J Neurophysiol. Nov;94(5):3628-36.
Dombeck DA, Blanchard-Desce M, Webb WW. (2004). Optical recording of action potentials with second-harmonic generation microscopy.J Neurosci. Jan 24(4), 999-1003.
Levene MJ, Dombeck DA, Kasischke KA, Molloy RP, Webb WW. (2004). In vivo multiphoton microscopy of deep brain tissue. J Neurophysiol. 91, 1908-1912.