Segraves, Mark, PhD
Cook Hall 2-137 Evanston
|Areas of Research||
Cell Imaging & Electrophysiology, Motor Control, Systems Neuroscience, Vision Science
|NU Scholar Profile|
|Recent Publications on PubMed|
Systems and cognitive neuroscience; sensorimotor integration; selection and control of eye movements in primates
The generation of eye movements is an important function of the brain’s control systems. My laboratory uses the eye movement system as a model for how the brain of primates, including man, controls a variety of movements. Our work focuses upon areas of the rhesus monkey’s prefrontal cortex and midbrain that help to control eye movements. We use behavioral and neurophysiological techniques in awake, behaving monkeys to allow us to examine the processing of information taking place within these areas, and to enable us to understand the role these neural structures perform in the complex network of connections that make up the oculomotor system.
Recent experiments from this laboratory have:
Described neuronal activity in the cortical frontal eye field related to the selection of eye movement targets while monkeys look at natural images such as a face or visual landscape.
Used microinjections of excitatory and inhibitory drugs to demonstrate the importance of frontal eye field activity for the generation of both visually-guided and memory-guided eye movements.
Identified and characterized the population of frontal eye field neurons that project to the superior colliculus as well as characterizing the functional activity of collicular neurons that receive frontal eye field input.
These studies provide basic knowledge about the processes our brain uses to select and control movements. They afford a unique opportunity to examine the interactions taking place within cortical and subcortical regions that integrate sensory and cognitive information to produce a quantifiable motor event.