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Learning / Memory
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Molecular Mechanisms of Synaptic Plasticity
My laboratory is studying the neurobiology of associative learning in the young and aging mammalian brain with in vivo and in vitro techniques using eyeblink conditioning, spatial learning and fear conditioning as behavioral model systems.
We use conventional and immunogold serial section electron microscopy to examine the role of synapses in maintaining cognitive function throughout life.Synaptic substrates of age-related memory deficits
In vivo studies of dynamic cell-cell interactions involved in brain plasticity and degeneration
The neurobiology and biomechanics of active sensing behaviors
Investigating the cortical foundations of higher level language processing, insight in problem solving, and creative thinking generally; understanding how individual differences in personality and mood modulate these processes; analyzing neural bases of hemispheric differences.
Cell and structural biology of Alzheimer’s disease; memory-linked synapse structure and signal transduction
Neural Encoding of Speech and Music and its Plasticity
The main goal of this laboratory is to understand the role of specific types of interneurons in the regulation of hippocampal network function.
The main focus the lab is the study of the ion channels expressed in dendrites of cells of the central nervous system and how they influence the physiological properties (pace-making, synaptic integration and plasticity, network properties) of neurons.
One current focus is on the networks that mediate spatial attention and the right hemisphere dominance for hemispatial neglect. Another is on a language-based dementia known as primary progressive aphasia.
Our sensory-motor is equipped with a powerful machinery that modifies the previously acquired motor programs so as to compensate for changes in the body and in the surrounding environment. The activities of our research group are directed at understanding the biological and computational mechanisms underlying this remarkable ability to learn and adapt.
Behavioral and neural analyses in investigations of phenomena such as memory encoding; explicit versus implicit memory retrieval; consolidation; memory processing during sleep; perceptual, conceptual, and affective priming; subliminal perception; and plasticity of attention and perception.
Signal transduction mechanisms regulating the development and structural plasticity of excitatory synapses
Our lab combines genetic, imaging and electrophysiological techniques to study cellular questions related to sensory processing in the rat and mouse barrel cortex, a primary somatosensory area representing the rodent facial whiskers.
Cell Biological mechanisms of memory
Cognitive neuroscience of human memory examined with functional neuroimaging, neuropsychological studies and computational modeling of cognitive processes.
Uncovering the molecular networks in brain synapses that are the substrate of learning and memory
Dendritic processing of synaptic inputs in hippocampal pyramidal neurons using patch-clamp recording, electron microscopy, and computer modeling
My laboratory studies the molecular and physiological properties of receptor proteins that underlie excitatory synaptic transmission in the mammalian brain.
Gene regulation in nervous system development and function; nerve-muscle induction mechanisms; sympathetic nervous system development and growth factor signaling
Our laboratory studies neuroplasticity or changes in the properties of individual neurons and their connections.
Research in this laboratory aims to determine how synaptic input is processed in intact animals and how processing changes with during learning and memory.
Investigating mechanisms of naming ability as it is affected by neurodegenerative brain disease in the syndromes of Primary Progressive Aphasia, Frontotemporal Dementia and Alzheimer's Disease.
Behavioral indices of naming and other language functions are compared to functional and structural neuroimaging in collaboration with other investigators.
Neurobiology of Associative Learning
Functional neuroanatomy of speech perception; auditory processing disorders; lexical tone perception; second language acquisition; music perception
We study neuroendocrine control of synaptic structure and function in brain areas related to memory, epilepsy, and drug addiction. We use a multidisciplinary approach including confocal and electron microscopy, cellular electrophysiology, biochemistry, and behavioral studies.
Auditory perceptual learning, auditory perception in individuals with language and listening disorders, psychoacoustics
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Northwestern University Interdepartmental Neuroscience Program , 320 East Superior Street, 5-474 Chicago, IL 60611-3010
Phone: 312-503-4300 (Chicago) 847-491-2862 (Evanston) Fax: 312-503-7345 E-mail: neuro-info@northwestern.edu
Last updated 09/21/2007 World Wide Web Disclaimer and University Policy Statements © 2006 Northwestern University
Powered by ORIGAMI, a Northwestern University Academic Technologies Web Publishing Platform built on Plone
Links | Forms | NUIN Newsletter | Employment | Contact Us | Site Map
Northwestern Home | Northwestern Calendar: Plan-It Purple | Northwestern Sites A-Z | Northwestern Search
Northwestern University Interdepartmental Neuroscience Program , 320 East Superior Street, 5-474 Chicago, IL 60611-3010
Phone: 312-503-4300 (Chicago) 847-491-2862 (Evanston) Fax: 312-503-7345 E-mail: neuro-info@northwestern.edu
Last updated 09/21/2007 World Wide Web Disclaimer and University Policy Statements © 2006 Northwestern University
Powered by ORIGAMI, a Northwestern University Academic Technologies Web Publishing Platform built on Plone